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LDN 193188

Cat. No. 5631 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of phosphatidylcholine transfer protein (PC-TP)
化学名： 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LDN 193188

LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.

技术数据 for LDN 193188

分子量 494.35
公式 C20H17Cl2N5O4S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1267610-30-9
PubChem ID 66958626
InChI Key COTBDKMEUUNJTI-UHFFFAOYSA-N
Smiles O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LDN 193188

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.44 100

制备储备液 for LDN 193188

以下数据基于产品分子量 494.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.23 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for LDN 193188

参考文献是支持产品生物活性的出版物。

Shishova et al (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54 664 PMID: 21538437

Wagle et al (2008) Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 383 85 PMID: 18762160

If you know of a relevant reference for LDN 193188, please let us know.

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关键词: LDN 193188, LDN 193188 supplier, LDN193188, inhibitors, inhibits, phosphatidylcholine, transfer, protein, PC-TP, glucose, metabolism, insulin, Other, Lipid, Metabolism, 5631, Tocris Bioscience

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