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Submit ReviewLDN 212320
说明： Increases EAAT2 expression; neuroprotective
化学名： 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
纯度： ≥98% (HPLC)
生物活性 for LDN 212320
LDN 212320 is a increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
技术数据 for LDN 212320
| 分子量 | 293.39 |
| 公式 | C17H15N3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 894002-50-7 |
| PubChem ID | 7207425 |
| InChI Key | DUUQLWDHNYFUPP-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LDN 212320
参考文献 for LDN 212320
参考文献是支持产品生物活性的出版物。
Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689 PMID: 22924507
Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774 PMID: 21875806
Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99
Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103
关键词: LDN 212320, LDN 212320 supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Glutamate, 5082, Tocris Bioscience
1 篇 LDN 212320 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LDN 212320 的部分引用包括：
Matthew P et al (2021) The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics. Front Cell Neurosci 15 661412 PMID: 33841104
LDN 212320 的评论
平均评分: 4 (Based on 1 Review.)
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Using LDN 212320 to increase GLT-1.
By
Crystal Wilkie on 01/12/2018
种属： Mouse
We used it to increase GLT-1 in mice brains. So far it has significantly increased GLT-1 after one injection.
It's hard to dissolve so we dissolved it in 100ul of DMSO first before adding the vehicle.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.