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Submit ReviewLG 101506
说明： Selective RXR modulator
别名： LG 1506
化学名： (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
纯度： ≥98% (HPLC)
生物活性 for LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
技术数据 for LG 101506
| 分子量 | 420.53 |
| 公式 | C25H34F2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 331248-11-4 |
| PubChem ID | 9845057 |
| InChI Key | BHIBZAZKKARFIM-XRYBSMBUSA-N |
| Smiles | CC(C)(C)C1=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LG 101506
参考文献 for LG 101506
参考文献是支持产品生物活性的出版物。
Michellys et al (2003) Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 46 2683 PMID: 12801232
Leibowitz et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147 1044 PMID: 16269450
Pinaire et al (2007) Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 94156 PMID: 17497022
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关键词: LG 101506, LG 101506 supplier, LG101506, retinoid, x, receptors, rxr, modulators, rxra, rxrb, rxrg, rxralpha, rxrbeta, rxrgamma, rxrα, rxrβ, rxrγ, LG1506, LG_1506, LG, 1506, Retinoid, X, Receptor, 3508, Tocris Bioscience
1 篇 LG 101506 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LG 101506 的部分引用包括：
Ronn et al (2015) Retinoic Acid regulates hematopoietic development from human pluripotent stem cells. Development 4 269 PMID: 25680478
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.