LIH 383 最新

Cat. No. 8095 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Atypical chemokine receptor (ACKR3) agonist

纯度： ≥95% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LIH 383

LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC₅₀ = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC₅₀ values are 1.2 nM and 2.2 nM, respectively). In a rat ex vivo model, LIH 383 increases the availability and signaling of opioid peptides at classical receptors.

许可信息

Sold under patent license from Luxembourg Institute of Health.

技术数据 for LIH 383

分子量	997.23
公式	C₄₅H₇₂N₁₆O₈S
序列	FGGFMRRK (Modification: Lys-8 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2866266-58-0
InChI Key	HKVZPBVWPFDBBQ-LBBUGJAGSA-N
Smiles	O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LIH 383

溶解性	Soluble to 2 mg/ml in water

产品说明书 for LIH 383

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LIH 383

参考文献是支持产品生物活性的出版物。

Meyrath et al (2020) The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat.Commun. 11 3033 PMID: 32561830

Kleist et al (2022) Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science 377 222 PMID: 35857540

If you know of a relevant reference for LIH 383, please let us know.

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关键词: LIH 383, LIH 383 supplier, LIH383, agonists, ACKR3, cxcr7, chemokines, atypical, chemokine, receptor, CXC, Receptors, potent, selective, opioid, peptides, Chemokine, 8095, Tocris Bioscience

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