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Liquiritigenin

Cat. No. 3819 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3819 has been discontinued.

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说明： Selective ERβ agonist
化学名： (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Liquiritigenin

Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

技术数据 for Liquiritigenin

分子量 256.25
公式 C15H12O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 578-86-9
PubChem ID 114829
InChI Key FURUXTVZLHCCNA-AWEZNQCLSA-N
Smiles OC(C=C3)=CC=[C@@]3[C@H](C2)OC1=CC(O)=CC=C1C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Liquiritigenin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Liquiritigenin

参考文献是支持产品生物活性的出版物。

Yahara and Nishioka (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108

Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49 PMID: 18177995

Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165 PMID: 18332856

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关键词: Liquiritigenin, Liquiritigenin supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory, Estrogen, and, Related, Receptors, 3819, Tocris Bioscience

1 篇 Liquiritigenin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Liquiritigenin 的部分引用包括：

Gong et al (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12 e001 PMID: 25363786

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Pathways for Liquiritigenin

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.