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LLY 507

Cat. No. 5365 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5365 has been discontinued.

View all Other Lysine Methyltransferases products.
说明： Potent SMYD2 inhibitor
化学名： 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for LLY 507

LLY 507 is a potent SMYD2 inhibitor (IC50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary on the SGC website.

External Portal Information for LLY 507

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LLY 507 is reviewed on the chemical probes website.

技术数据 for LLY 507

分子量 574.76
公式 C36H42N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1793053-37-8
PubChem ID 91623361
InChI Key PNYRDVBFYVDJJI-UHFFFAOYSA-N
Smiles CC(C5=C4C=CC=C5)=CN4CCN(CC3)CCN3C1=C(C2=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C2)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for LLY 507

参考文献是支持产品生物活性的出版物。

Nguyen et al (2015) LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2. J.Biol.Chem. 290 13641 PMID: 25825497

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关键词: LLY 507, LLY 507 supplier, LLY507, potent, selective, SMYD2, inhibitors, inhibits, lysine, methyltransferases, p53, Other, Lysine, Methyltransferases, 5365, Tocris Bioscience

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