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说明： Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
化学名： 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
纯度： ≥98% (HPLC)
生物活性 for LM 10
LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
技术数据 for LM 10
| 分子量 | 229.21 |
| 公式 | C11H8FN5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1316695-35-8 |
| PubChem ID | 91885138 |
| InChI Key | FSGAFWYMLAWNJM-UHFFFAOYSA-N |
| Smiles | FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LM 10
参考文献 for LM 10
参考文献是支持产品生物活性的出版物。
Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 22308364
Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 21726069
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关键词: LM 10, LM 10 supplier, LM10, selective, 2,3-dioxygenase, TDO, inhibitors, inhibits, orally, bioavailable, anticancer, cancer, immunology, Tryptophan, 2,3, dioxygenase, Immune, Checkpoints, 5794, Tocris Bioscience
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