LOE 908 hydrochloride

Name: LOE 908 hydrochloride
Brand: Tocris Bioscience
SKU: 2314

Cat. No. 2314 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2314 has been discontinued.

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说明： Broad spectrum cation channel blocker; neuroprotective

化学名： 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for LOE 908 hydrochloride

LOE 908 hydrochloride is a broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na⁺ and K⁺ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

技术数据 for LOE 908 hydrochloride

分子量	749.29
公式	C₄₁H₄₈N₂O₉.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	143482-60-4
PubChem ID	56846451
InChI Key	UDKSNBMNKLDHNK-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(CCN(CCC2=C(OC)C(OC)=C(OC)C=C2)C(=O)C(C2=CC=CC=C2)C2=NCCC3=CC(OC)=C(OC)C=C23)C(OC)=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for LOE 908 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LOE 908 hydrochloride

参考文献是支持产品生物活性的出版物。

Christensen et al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316 PMID: 15755315

Krause et al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659 PMID: 9535721

Tatlisumak et al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 178 107 PMID: 11018702

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关键词: LOE 908 hydrochloride, LOE 908 hydrochloride supplier, Broad, spectrum, cation, channels, blockers, neuroprotective, modulators, VDAC, store-operated, calcium, SOCs, voltage-operated, VOCs, non-selective, NSCCs, LOE908, hydrochloride, Other, Channel, Modulators, 2314, Tocris Bioscience

2 篇 LOE 908 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LOE 908 hydrochloride 的部分引用包括：

Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590

Harper and Poole (2010) Protein kinase Ctheta negatively regulates store-independent Ca²⁺ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem 285 19865 PMID: 20388711