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Submit ReviewLofepramine
说明： 5-HT and NA reuptake inhibitor (SNRI)
别名： Lopramine,Leo 640
化学名： 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
纯度： ≥99% (HPLC)
生物活性 for Lofepramine
Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.
技术数据 for Lofepramine
| 分子量 | 418.97 |
| 公式 | C26H27N2OCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 23047-25-8 |
| PubChem ID | 3947 |
| InChI Key | SAPNXPWPAUFAJU-UHFFFAOYSA-N |
| Smiles | CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Lofepramine
参考文献 for Lofepramine
参考文献是支持产品生物活性的出版物。
Leonard (1987) A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 2 281 PMID: 2891742
Badawy et al (1991) The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 42 921 PMID: 1867646
Kelly and Leonard (1999) An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 9 101 PMID: 10082234
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关键词: Lofepramine, Lofepramine supplier, 5-HT, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, Leo640, Lopramine, Leo, 640, 2545, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.