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Submit ReviewLP 20 hydrochloride
说明： Selective 5-HT7 ligand
化学名： 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for LP 20 hydrochloride
Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).
许可信息
Sold under license from the University of Bari
技术数据 for LP 20 hydrochloride
| 分子量 | 304.81 |
| 公式 | C17H20N2O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1386928-34-2 |
| PubChem ID | 22001617 |
| InChI Key | KXZUJPBDJNUNCN-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LP 20 hydrochloride
参考文献 for LP 20 hydrochloride
参考文献是支持产品生物活性的出版物。
Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316
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关键词: LP 20 hydrochloride, LP 20 hydrochloride supplier, LP20, 5-HT7, ligands, selective, serotonergics, Receptors, 4704, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.