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Submit ReviewLP 44
说明： High affinity 5-HT7 agonist
化学名： 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for LP 44
High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
许可信息
Sold under license from the University of Bari
技术数据 for LP 44
| 分子量 | 488.13 |
| 公式 | C27H37N3OS.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 824958-12-5 |
| PubChem ID | 11225543 |
| InChI Key | DWGKCWWWKHCVDH-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCN3CCN(C4=C(SC)C=CC=C4)CC3)NC1CCCC2=C1C=CC=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LP 44
参考文献 for LP 44
参考文献是支持产品生物活性的出版物。
Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616 PMID: 15588097
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关键词: LP 44, LP 44 supplier, High, affinity, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP44, 2534, Tocris Bioscience
2 篇 LP 44 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LP 44 的部分引用包括：
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Mol Med 3 e00103 PMID: 25692021
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.