LSN 2463359

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10 mg / $181Ships in 5-7 Business Days
50 mg / $736In Stock
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说明: Potent and selective positive allosteric modulator of mGlu5 receptors
化学名: N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide
纯度: ≥99% (HPLC)
说明书
引用文献
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文献 (5)

生物活性 for LSN 2463359

LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.

技术数据 for LSN 2463359

分子量 265.31
公式 C16H15N3O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1401031-52-4
PubChem ID 72551298
InChI Key STAFRSGTRKNXHF-UHFFFAOYSA-N
Smiles O=C(NC(C)C)C(C=C2)=NC=C2C#CC1=CC=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LSN 2463359

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.53 100
ethanol 5.31 20

制备储备液 for LSN 2463359

以下数据基于产品分子量 265.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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关键词: LSN 2463359, LSN 2463359 supplier, LSN2463359, potent, selective, positive, allosteric, modulator, PAM, MGLU5, brain, penetrant, orally, active, schizophrenia, Glutamate, (Metabotropic), Group, I, Receptors, 5275, Tocris Bioscience

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