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Submit ReviewLu AA 47070
Discontinued Product
4783 has been discontinued.
View all Adenosine A<sub>2A</sub> Receptors products.
说明： Prodrug of a potent and selective adenosine A2A receptor antagonist
化学名： 4-[(3,3-Dimethyl-1-oxobutyl)amino]-3,5-difluoro-N-[3-[(phosphonooxy)methyl]-2(3H)-thiazolylidene]benzamide
纯度： ≥98% (HPLC)
生物活性 for Lu AA 47070
Prodrug of a potent and selective adenosine A2A receptor antagonist (Ki values are 5.9, 260, 410 and <10,000 nM for A2A, A2B, A1 and A3 receptors respectively. Reverses parkinsonian motor impairment and motivational effects produced by dopamine D2 receptor blockade in rats. Orally bioavailable.
技术数据 for Lu AA 47070
| 分子量 | 463.39 |
| 公式 | C17H20F2N3O6PS |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 913842-25-8 |
| PubChem ID | 11947802 |
| InChI Key | MSWIQSFUBYCFJE-UHFFFAOYSA-N |
| Smiles | FC1=C(NC(CC(C)(C)C)=O)C(F)=CC(C(/N=C2\SC=CN2COP(O)(O)=O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Lu AA 47070
参考文献 for Lu AA 47070
参考文献是支持产品生物活性的出版物。
Sams et al (2011) Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA2A receptor antagonist. J.Med.Chem. 54 751 PMID: 21210664
Collins et al (2012) The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by DA D2 receptor blockade. Pharmacol.Biochem.Behav. 100 498 PMID: 22037410
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关键词: Lu AA 47070, Lu AA 47070 supplier, LuAA47070, prodrug, potent, selective, adenosine, A2A, receptors, antagonists, parkinson's, disease, antiparkinson, parkinsonian, orally, bioavailable, Adenosine, Receptors, 4783, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.