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LY 2119620

Cat. No. 6964 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of M2 and M4 receptors
化学名： 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LY 2119620

LY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.

技术数据 for LY 2119620

分子量 437.94
公式 C19H24ClN5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 886047-22-9
PubChem ID 57664406
InChI Key TYTGOXSAAQWLPJ-UHFFFAOYSA-N
Smiles CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 2119620

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.79 100
1eq. HCl 43.79 100

制备储备液 for LY 2119620

以下数据基于产品分子量 437.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for LY 2119620

参考文献是支持产品生物活性的出版物。

Croy et al (2014) Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol.Pharmacol. 86 106 PMID: 24807965

Kruse et al (2013) Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 101 PMID: 24256733

If you know of a relevant reference for LY 2119620, please let us know.

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关键词: LY 2119620, LY 2119620 supplier, LY2119620, muscarinic, acetylcholine, ach, receptor, M2, M4, positive, allosteric, modulators, PAM, potentiates, modulates, mAChRs, Receptors, 6964, Tocris Bioscience

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