LY 2365109 hydrochloride

Cat. No. 3397 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective GlyT1 inhibitor

化学名： N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LY 2365109 hydrochloride

LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor (IC₅₀ values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.

技术数据 for LY 2365109 hydrochloride

分子量	421.91
公式	C₂₂H₂₇NO₅.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1779796-27-8
PubChem ID	56972229
InChI Key	ZQVOAGQZHDAFRM-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=C(OCCN(C)CC(O)=O)C=CC(C2=CC(OCO3)=C3C=C2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 2365109 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	42.19	100
	ethanol	21.1	50

制备储备液 for LY 2365109 hydrochloride

以下数据基于产品分子量 421.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.85 mL	23.7 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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产品说明书 for LY 2365109 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LY 2365109 hydrochloride

参考文献是支持产品生物活性的出版物。

Perry et al (2008) Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 55 743 PMID: 18602930

If you know of a relevant reference for LY 2365109 hydrochloride, please let us know.

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