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Submit ReviewLY 2389575 hydrochloride
Discontinued Product
4969 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Selective negative allosteric modulator of mGlu3 receptors
化学名： (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for LY 2389575 hydrochloride
LY 2389575 hydrochloride is a selective negative allosteric modulator of mGlu3 (IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.
技术数据 for LY 2389575 hydrochloride
| 分子量 | 438.58 |
| 公式 | C15H15BrCl2N4.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 885104-09-6 |
| PubChem ID | 11503054 |
| InChI Key | IRIBLLOEUZMCQY-ZOWNYOTGSA-N |
| Smiles | ClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 2389575 hydrochloride
参考文献 for LY 2389575 hydrochloride
参考文献是支持产品生物活性的出版物。
Caraci et al (2011) Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGl Mol.Pharmacol. 79 618 PMID: 21159998
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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