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说明： Selective secreted phospholipase A2 (sPLA2) inhibitor
化学名： [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonic acid
纯度： ≥97% (HPLC)
生物活性 for LY 311727
Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 values are <1 μM for group IIA and <50 μM for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μM.
技术数据 for LY 311727
| 分子量 | 430.43 |
| 公式 | C22H27N2O5P |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 164083-84-5 |
| PubChem ID | 155922 |
| InChI Key | OPWQYOUZRHDKBR-UHFFFAOYSA-N |
| Smiles | NC(CC2=C(CC)N(CC3=CC=CC=C3)C1=CC=C(OCCCP(O)(O)=O)C=C12)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 311727
参考文献 for LY 311727
参考文献是支持产品生物活性的出版物。
Schevitz et al (1995) Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol. 2 429 PMID: 7664101
Bernatchez et al (2001) VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. Br.J.Pharmacol. 134 197 PMID: 11522612
Bridonneau et al (1997) High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2). J.Med.Chem 41 778
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关键词: LY 311727, LY 311727 supplier, LY311727, secreted, phospholipases, a2, sPLA2, PLA2, inhibitors, inhibits, Phospholipases, 3627, Tocris Bioscience
1 篇 LY 311727 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 311727 的部分引用包括：
Mock et al (2013) Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2 responsive liposome in prostate cancer. Integr Biol (Camb) 5 172 PMID: 22890797
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