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说明： Selective secreted phospholipase A2 (sPLA2) inhibitor
别名： Varespladib
化学名： 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic aci
纯度： ≥98% (HPLC)
生物活性 for LY 315920
Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.
技术数据 for LY 315920
| 分子量 | 380.39 |
| 公式 | C21H20N2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 172732-68-2 |
| PubChem ID | 155815 |
| InChI Key | BHLXTPHDSZUFHR-UHFFFAOYSA-N |
| Smiles | OC(COC1=C2C(N(CC3=CC=CC=C3)C(CC)=C2C(C(N)=O)=O)=CC=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 315920
参考文献 for LY 315920
参考文献是支持产品生物活性的出版物。
Snyder et al (1999) Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J.Pharmacol.Exp.Ther. 288 1117 PMID: 10027849
Oslund et al (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J.Med.Chem. 51 4708 PMID: 18605714
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关键词: LY 315920, LY 315920 supplier, LY315920, selective, secreted, phospholipase, A2, sPLA2, inhibitors, inhibits, orally, available, Varespladib, Phospholipases, 5313, Tocris Bioscience
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