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Submit ReviewLY 341495 disodium salt
说明： Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
化学名： (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
纯度： ≥97% (HPLC)
生物活性 for LY 341495 disodium salt
LY 341495 disodium salt is a Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).
技术数据 for LY 341495 disodium salt
| 分子量 | 397.33 |
| 公式 | C20H17NNa2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| PubChem ID | 90488907 |
| InChI Key | UYFREPWOVKMBOV-AUZVYACCSA-L |
| Smiles | [Na+].[Na+].[H][C@@]1(C[C@@H]1C([O-])=O)[C@@](N)(CC1C2=CC=CC=C2OC2=C1C=CC=C2)C([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 341495 disodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 39.73 | 100 |
制备储备液 for LY 341495 disodium salt
以下数据基于产品分子量 397.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.17 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for LY 341495 disodium salt
参考文献 for LY 341495 disodium salt
参考文献是支持产品生物活性的出版物。
Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 37 1445 PMID: 9886667
Ornstein et al (1998) 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav J.Med.Chem. 41 358 PMID: 9464367
Johnson et al (1999) [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38 1519 PMID: 10530814
If you know of a relevant reference for LY 341495 disodium salt, please let us know.
关键词: LY 341495 disodium salt, LY 341495 disodium salt supplier, LY341495, disodium, salt, group, II, mglu, metabotropic, glutamate, receptors, antagonists, Glutamate, (Metabotropic), Group, Receptors, 4062, Tocris Bioscience
8 篇 LY 341495 disodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 341495 disodium salt 的部分引用包括：
Nanna et al (2017) Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms. Glia 65 1668-1681 PMID: 28744903
Manookin et al (2018) Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron 97 1327 PMID: 29503188
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823
David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183
Michel K et al (2020) Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell Rep 32 108182 PMID: 32966786
Javier et al (2020) Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells. Cell Chem Biol 27 1308-1317.e4 PMID: 32726588
Jean-Philippe et al (2021) Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations. Cell Rep 36 109648 PMID: 34469715
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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