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说明： Potent and highly selective group II mGlu agonist
化学名： (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for LY 354740
LY 354740 is a highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and > 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.
技术数据 for LY 354740
| 分子量 | 185.18 |
| 公式 | C8H11NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 176199-48-7 |
| PubChem ID | 213056 |
| InChI Key | VTAARTQTOOYTES-RGDLXGNYSA-N |
| Smiles | N[C@]1([C@@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 354740
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 18.52 | 100 |
制备储备液 for LY 354740
以下数据基于产品分子量 185.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.4 mL | 27 mL | 54 mL |
| 5 mM | 1.08 mL | 5.4 mL | 10.8 mL |
| 10 mM | 0.54 mL | 2.7 mL | 5.4 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.08 mL |
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产品说明书 for LY 354740
参考文献 for LY 354740
参考文献是支持产品生物活性的出版物。
Schoepp et al (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors. Neuropharmacology 36 1 PMID: 9144636
Helton et al (1998) Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 284 651 PMID: 9454811
Klodzinska et al (1999) Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology 38 1831 PMID: 10608278
If you know of a relevant reference for LY 354740, please let us know.
关键词: LY 354740, LY 354740 supplier, Potent, selective, group, II, mGlur, agonists, Group, Receptors, mGlu2, mGluR2, mGlu3, mGluR3, Glutamate, Metabotropic, LY354740, (Metabotropic), 3246, Tocris Bioscience
5 篇 LY 354740 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 354740 的部分引用包括：
Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653
Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741 PMID: 25788690
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Dornier (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nat Commun 8 2255 PMID: 29269878
Copeland et al (2015) Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Sci Rep 92 16 PMID: 25576798
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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