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Submit ReviewLY 379268 disodium salt
说明： Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)
化学名： (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
纯度： ≥98% (HPLC)
生物活性 for LY 379268 disodium salt
LY 379268 disodium salt is a sodium salt of LY 379268 (Cat. No. 2453), a highly selective group II mGlu receptor agonist.
技术数据 for LY 379268 disodium salt
| 分子量 | 231.11 |
| 公式 | C7H7NNa2O5 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 10197984 |
| InChI Key | YASVRZWVUGJELU-MDASVERJSA-N |
| Smiles | [H][C@]12[C@]([C@H]2[C@](O[Na])=O)([H])[C@@]([C@](O[Na])=O)(N)CO1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 379268 disodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 23.11 | 100 |
制备储备液 for LY 379268 disodium salt
以下数据基于产品分子量 231.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.33 mL | 21.63 mL | 43.27 mL |
| 5 mM | 0.87 mL | 4.33 mL | 8.65 mL |
| 10 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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产品说明书 for LY 379268 disodium salt
参考文献 for LY 379268 disodium salt
参考文献是支持产品生物活性的出版物。
Bond et al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 273 PMID: 10515191
Bond et al (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 294 800 PMID: 10945827
Collado et al (2002) (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 45 3619 PMID: 12166935
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关键词: LY 379268 disodium salt, LY 379268 disodium salt supplier, LY379268, disodium, salt, 2Na, selective, group, II, agonists, Group, Receptors, mGlu2, mGluR2, mGlu3, mGluR3, Glutamate, Metabotropic, (Metabotropic), 5064, Tocris Bioscience
2 篇 LY 379268 disodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 379268 disodium salt 的部分引用包括：
Craig W et al (2021) Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus. Biol Psychiatry 90 385-398 PMID: 33965197
Javier et al (2020) Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells. Cell Chem Biol 27 1308-1317.e4 PMID: 32726588
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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