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Submit ReviewLY 456236 hydrochloride
说明： Selective mGlu1 antagonist
别名： MPMQ hydrochloride
化学名： 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for LY 456236 hydrochloride
LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.
技术数据 for LY 456236 hydrochloride
| 分子量 | 317.77 |
| 公式 | C16H15N3O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 338736-46-2 |
| PubChem ID | 9926998 |
| InChI Key | AVKFOWUSTVWZQN-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 456236 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 6.36 | 20 |
制备储备液 for LY 456236 hydrochloride
以下数据基于产品分子量 317.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.73 mL | 78.67 mL | 157.35 mL |
| 1 mM | 3.15 mL | 15.73 mL | 31.47 mL |
| 2 mM | 1.57 mL | 7.87 mL | 15.73 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.15 mL |
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产品说明书 for LY 456236 hydrochloride
参考文献 for LY 456236 hydrochloride
参考文献是支持产品生物活性的出版物。
Shannon et al (2005) Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 49 188 PMID: 16011839
Bertorelli et al (2005) Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects. Neuropharmacology 49 231
If you know of a relevant reference for LY 456236 hydrochloride, please let us know.
关键词: LY 456236 hydrochloride, LY 456236 hydrochloride supplier, Selective, mGlu1, mGluR1, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic, LY456236, hydrochloride, MPMQ, (Metabotropic), 2390, Tocris Bioscience
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LY 456236 hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Action via NMDA receptors.
By
Sergiy Sylantyev on 04/02/2021
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Hippocampus
1 microM LY 456236 was tested on action potentials generated by current injection into CA3 hippocampal neuron. Application of LY increased significantly a number of action potentials. This effect disappeared after partial block of NMDA receptors. Illustration: control recording of action potentials (top) and recording with LY 456236 (bottom).
Can be easily diluted, no problem with long-time storage in aliquots.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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