M 084 hydrochloride

Cat. No. 5807 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic

化学名： N-Butyl-1H-benzimidazol-2-amine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for M 084 hydrochloride

M 084 hydrochloride is a TRPC4/5 channel blocker (IC₅₀ values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

技术数据 for M 084 hydrochloride

分子量	225.72
公式	C₁₁H₁₅N₃.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1992047-63-8
PubChem ID	121513894
InChI Key	DMLSYUAQEOLJQC-UHFFFAOYSA-N
Smiles	CCCCNC1=NC2=CC=CC=C2N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for M 084 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	22.57	100
	DMSO	22.57	100

制备储备液 for M 084 hydrochloride

以下数据基于产品分子量 225.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.43 mL	22.15 mL	44.3 mL
5 mM	0.89 mL	4.43 mL	8.86 mL
10 mM	0.44 mL	2.22 mL	4.43 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

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产品说明书 for M 084 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for M 084 hydrochloride

参考文献是支持产品生物活性的出版物。

Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID: 25816897

Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID: 26317356

If you know of a relevant reference for M 084 hydrochloride, please let us know.

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关键词: M 084 hydrochloride, M 084 hydrochloride supplier, M084, hydrochloride, TRPC4/5, blockers, inhibitors, inhibits, transient, receptor, potential, channels, canonical, TRPC, 5807, Tocris Bioscience

2 篇 M 084 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 M 084 hydrochloride 的部分引用包括：

Melitta et al (2022) Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of Ca2+ into Neurons. Int J Mol Sci 23 PMID: 36077460

Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946

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