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说明： Histone deacetylase inhibitor
化学名： 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
纯度： ≥98% (HPLC)
生物活性 for M 344
M 344 is a histone deacetylase inhibitor (IC50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
技术数据 for M 344
| 分子量 | 307.39 |
| 公式 | C16H25N3O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 251456-60-7 |
| PubChem ID | 3994 |
| InChI Key | MXWDSZWTBOCWBK-UHFFFAOYSA-N |
| Smiles | O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for M 344
参考文献 for M 344
参考文献是支持产品生物活性的出版物。
Jung et al (1999) Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J.Med.Chem. 42 4669 PMID: 10579829
Takai et al (2006) M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol.Oncol. 101 108 PMID: 16263156
Riessland et al (2006) The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum.Genet. 120 101 PMID: 16724231
关键词: M 344, M 344 supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, M344, epigenetics, Non-selective, HDACs, Non-Selective, 2771, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.