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Discontinued Product
0711 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Potent group II mGlu agonist; also group III mGlu antagonist
化学名： (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
纯度： ≥96% (HPLC)
生物活性 for MAP4
MAP4 is a selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
技术数据 for MAP4
| 分子量 | 197.13 |
| 公式 | C5H12NO5P |
| 储存 | Store at RT |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 157381-42-5 |
| PubChem ID | 1795545 |
| InChI Key | HONKEGXLWUDTCF-YFKPBYRVSA-N |
| Smiles | N[C@](CCP(O)(O)=O)(C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MAP4
参考文献 for MAP4
参考文献是支持产品生物活性的出版物。
Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809 PMID: 7921606
Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79 PMID: 8864697
Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5 PMID: 7753406
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
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关键词: MAP4, MAP4 supplier, Potent, group, II, mGlur, agonists, specific, III, antagonists, Selective, potent, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu4, mGluR4, mGlu6, mGluR6, mGlu7, mGluR7, mGlu8, mGlkuR8, (Metabotropic), 0711, Tocris Bioscience
1 篇 MAP4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MAP4 的部分引用包括：
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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