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说明： Dynamin-related GTPase DRP1 partial inhibitor
化学名： 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for MB 0223
MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.
技术数据 for MB 0223
| 分子量 | 457.59 |
| 公式 | C26H27N5OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2247732-89-2 |
| PubChem ID | 135368613 |
| InChI Key | SWLKFZCOJAYAMJ-UHFFFAOYSA-N |
| Smiles | CC1=CN(C(C(NC2=CC=C(C3=CN=CC=C3)C=C2)=O)=C1)CC4=CSC(N5CCCCC5)=N4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MB 0223
参考文献 for MB 0223
参考文献是支持产品生物活性的出版物。
Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID: 29601815
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关键词: MB 0223, MB 0223 supplier, MB0223, DRP1, dynamin, related, GTPase, inhibitors, inhibits, partial, mitochondrial, dynamics, division, Dynamin, 6799, Tocris Bioscience
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