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说明： Selective HDAC class IIa inhibitor
化学名： 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
纯度： ≥96% (HPLC)
生物活性 for MC 1568
MC 1568 is a selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.
技术数据 for MC 1568
| 分子量 | 314.31 |
| 公式 | C17H15FN2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 852475-26-4 |
| PubChem ID | 11381449 |
| InChI Key | QRDAPCMJAOQZSU-KQQUZDAGSA-N |
| Smiles | CN1C=C(/C=C/C(C2=CC(F)=CC=C2)=O)C=C1/C=C/C(NO)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MC 1568
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.43 | 100 |
制备储备液 for MC 1568
以下数据基于产品分子量 314.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.82 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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产品说明书 for MC 1568
参考文献 for MC 1568
参考文献是支持产品生物活性的出版物。
Mai et al (2005) Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines. J.Med.Chem. 48 3344 PMID: 15857140
Mai et al (2007) Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol.Pharmacol. 72 1111 PMID: 17666592
Nebbioso et al (2009) Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO J. 10 776
If you know of a relevant reference for MC 1568, please let us know.
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关键词: MC 1568, MC 1568 supplier, MC1568, HDAC, selective, inhibitors, inhibits, histone, deacetylase, class, II, IIa, HDAC4, epigenetics, Class, HDACs, 4077, Tocris Bioscience
1 篇 MC 1568 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MC 1568 的部分引用包括：
Verónica et al (2020) Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo. Neuropharmacology 165 107922 PMID: 31923766
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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