MC 1742

Cat. No. 5727 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent class I and IIb HDAC inhibitor

化学名： 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MC 1742

MC 1742 is a potent class I and IIb HDAC inhibitor (IC₅₀ values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM.

技术数据 for MC 1742

分子量	395.47
公式	C₂₁H₂₁N₃O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1776116-74-5
PubChem ID	49769453
InChI Key	AOFVDNFTELWRHV-UHFFFAOYSA-N
Smiles	O=C(NC(SCCCCC(NO)=O)=N1)C=C1C(C=C2)=CC=C2C3=CC=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MC 1742

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	39.55	100

制备储备液 for MC 1742

以下数据基于产品分子量 395.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for MC 1742

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MC 1742

参考文献是支持产品生物活性的出版物。

Di Pompo et al (2015) Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J.Med.Chem. 58 4073 PMID: 25905694

Mai et al (2008) Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg.Med.Chem.Lett. 18 2530 PMID: 18381238

Mai et al (2006) Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J.Med.Chem. 49 6046 PMID: 17004718

If you know of a relevant reference for MC 1742, please let us know.

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关键词: MC 1742, MC 1742 supplier, MC1742, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, inhibitors, inhibits, histone, deacetylases, class, II, IIa, epigenetics, cancer, stem, cells, CSCs, osteogenic, differentiation, Cancer, Stem, Cells, Class, I, HDACs, 5727, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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