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Submit ReviewMcN-A 343
说明： Selective M1 muscarinic agonist
化学名： 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
纯度： ≥99% (HPLC)
生物活性 for McN-A 343
McN-A 343 is a selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.
技术数据 for McN-A 343
| 分子量 | 317.21 |
| 公式 | C14H18Cl2N2O2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 55-45-8 |
| PubChem ID | 5926 |
| InChI Key | CXFZFEJJLNLOTA-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for McN-A 343
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.72 | 100 |
制备储备液 for McN-A 343
以下数据基于产品分子量 317.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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产品说明书 for McN-A 343
参考文献 for McN-A 343
参考文献是支持产品生物活性的出版物。
Davies et al (2001) Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. J.Pharm.Pharmacol. 53 487 PMID: 11341365
Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531 PMID: 8981565
Micheletti and Schiavone (1990) Functional determination of McN-A-343 affinity for M1 muscarinic receptors. J.Pharmacol.Exp.Ther. 253 310 PMID: 1691785
If you know of a relevant reference for McN-A 343, please let us know.
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关键词: McN-A 343, McN-A 343 supplier, Selective, M1, muscarinic, agonists, Receptors, Acetylcholine, ACh, McNA343, 1384, Tocris Bioscience
2 篇 McN-A 343 的引用文献
引用文献是使用了 Tocris 产品的出版物。 McN-A 343 的部分引用包括：
Park et al (2013) Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Korean J Anesthesiol 38 1426 PMID: 23389690
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
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