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Submit ReviewMDL 72527
说明： Polyamine oxidase (PAO) inhibitor
化学名： N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride
生物活性 for MDL 72527
MDL 72527 is a polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo.
技术数据 for MDL 72527
| 分子量 | 265.23 |
| 公式 | C12H20N2.2HCl |
| 储存 | Store at +4°C |
| CAS Number | 93565-01-6 |
| PubChem ID | 3035046 |
| InChI Key | ITVRWVVFVHINOH-UHFFFAOYSA-N |
| Smiles | C=C=CCNCCCCNCC=C=C.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MDL 72527
参考文献 for MDL 72527
参考文献是支持产品生物活性的出版物。
Bey et al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1 PMID: 3965702
Dogan et al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765 PMID: 9930751
Basu et al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689 PMID: 19773450
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关键词: MDL 72527, MDL 72527 supplier, MDL72527, polyamine, oxidases, inhibitors, inhibits, POA, Other, Oxygenases/Oxidases, 3709, Tocris Bioscience
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