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Submit ReviewMDL 73005EF hydrochloride
说明： Potent and selective 5-HT1A partial agonist
化学名： 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
纯度： ≥98% (HPLC)
生物活性 for MDL 73005EF hydrochloride
MDL 73005EF hydrochloride is a potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.
技术数据 for MDL 73005EF hydrochloride
| 分子量 | 394.9 |
| 公式 | C20H26N2O4.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 102908-60-1 |
| PubChem ID | 56972149 |
| InChI Key | UEDYXFOPCMTXEH-UHFFFAOYSA-N |
| Smiles | Cl.O=C1CC2(CCCC2)CC(=O)N1CCNCC1COC2=C(O1)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MDL 73005EF hydrochloride
参考文献 for MDL 73005EF hydrochloride
参考文献是支持产品生物活性的出版物。
Buisson Defferier and Van den Buuse (1992) Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats. Eur.J.Pharmacol. 223 133 PMID: 1362161
Gartside et al (1990) Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo. Eur.J.Pharmacol. 191 391 PMID: 1964908
Van der Hooff and Galvan (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur.J.Pharmacol. 196 291 PMID: 1893914
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关键词: MDL 73005EF hydrochloride, MDL 73005EF hydrochloride supplier, Potent, selective, 5-HT1A, partial, agonists, Serotonin, Receptors, 5-HT1, MDL73005EF, hydrochloride, 0411, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.