Mecamylamine hydrochloride

Cat. No. 2843 21 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Non-competitive nAChR antagonist

化学名： (1R,2S,4S)-rel-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

引用文献 (21)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Mecamylamine hydrochloride

Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

技术数据 for Mecamylamine hydrochloride

分子量	203.75
公式	C₁₁H₂₁N.HCl
储存	Desiccate at RT
CAS Number	110691-49-1
PubChem ID	13221
InChI Key	LRJARFKQBBVCIV-FDYABGJLSA-N
Smiles	C[C@]1(NC)C(C)(C)[C@@H]2CC[C@H]1C2.Cl.C[C@@]1(NC)C(C)(C)[C@H]2CC[C@@H]1C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mecamylamine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	20.37	100
	DMSO	20.37	100

制备储备液 for Mecamylamine hydrochloride

以下数据基于产品分子量 203.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.91 mL	24.54 mL	49.08 mL
5 mM	0.98 mL	4.91 mL	9.82 mL
10 mM	0.49 mL	2.45 mL	4.91 mL
50 mM	0.1 mL	0.49 mL	0.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Mecamylamine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mecamylamine hydrochloride

参考文献是支持产品生物活性的出版物。

Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393 PMID: 17938901

Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395

If you know of a relevant reference for Mecamylamine hydrochloride, please let us know.

按标靶查看相关产品

关键词: Mecamylamine hydrochloride, Mecamylamine hydrochloride supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, 826-39-1, Nicotinic, Receptors, (Non-selective), 2843, Tocris Bioscience

21 篇 Mecamylamine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mecamylamine hydrochloride 的部分引用包括：

Sternfeld et al (2017) Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. Elife 6 PMID: 28195039

Stouffer et al (2015) Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543 PMID: 26503322

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206

Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331 PMID: 21610071

Pujala and Koyama (2019) Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth. Elife 8 PMID: 30801247

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Neurosci 10 e0131430 PMID: 26102354

Assous (2017) Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun 8 15860 PMID: 28604688

Dannenberg et al (2015) Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J Neurosci 35 8394 PMID: 26041909

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263

Lozovaya et al (2018) GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun 9 1422 PMID: 29651049

Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253 PMID: 27698417

Kam et al (2016) Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Proc Natl Acad Sci U S A 6 20119 PMID: 26818394

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurophysiol 112 8124 PMID: 26080439

Leão et al (2015) Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J Neurosci 113 971 PMID: 25392162

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Front Cell Neurosci 35 5680 PMID: 25855181

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6 PMID: 25709566

Bryant et al (2015) Cholinergic control of γ power in the midbrain spatial attention network. Elife 35 761 PMID: 25589769

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Sci Rep 4 PMID: 25723967

Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843 PMID: 24513971

Morris et al (2018) Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster. BMC Dev Biol 18 13 PMID: 29898654

Takahashi et al (2018) The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice. Int J Mol Sci 19 PMID: 29510587

您是否知道使用了 Tocris Mecamylamine hydrochloride 的优秀论文？请告知我们.