Mepyramine maleate

Name: Mepyramine maleate
Brand: Tocris Bioscience
SKU: 0660

Cat. No. 0660 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0660 has been discontinued.

View all Histamine H<sub>1</sub> Receptors products.

说明： Selective H₁ inverse agonist

别名： Pyrilamine maleate

化学名： 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate

说明书

引用文献 (5)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Mepyramine maleate

Mepyramine maleate is a selective inverse agonist for the H₁ receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC₅₀ = -7.94) and intracellular calcium mobilization. Sequesters G_q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

技术数据 for Mepyramine maleate

分子量	401.46
公式	C₁₇H₂₃N₃O.C₄H₄O₄
储存	Store at RT
CAS Number	59-33-6
PubChem ID	5284451
InChI Key	JXYWFNAQESKDNC-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Mepyramine maleate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mepyramine maleate

参考文献是支持产品生物活性的出版物。

Carlos et al (2004) Mepyramine, a histamine H₁ receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 279 34431 PMID: 15192105

Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Liu et al (1994) Does the [³H] mepyramine binding site represent the histamine H₁ receptor? Re-examination of the histamine H₂ receptor with qine J.Pharmacol.Exp.Ther. 268 959 PMID: 8114011

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关键词: Mepyramine maleate, Mepyramine maleate supplier, Selective, H1, inverse, agonists, Receptors, Histamine, histaminergic, Pyrilamine, maleate, 0660, Tocris Bioscience

5 篇 Mepyramine maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mepyramine maleate 的部分引用包括：

Kurtz et al (2014) Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation 21 593 PMID: 24702851

Littmann et al (2018) A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells. Sci Rep 8 17179 PMID: 30464299

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Brandt et al (2003) Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 112 1666 PMID: 14660743