Mepyramine maleate

Cat. No. 0660 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective H₁ inverse agonist

别名： Pyrilamine maleate

化学名： 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Mepyramine maleate

Mepyramine maleate is a selective inverse agonist for the H₁ receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC₅₀ = -7.94) and intracellular calcium mobilization. Sequesters G_q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

技术数据 for Mepyramine maleate

分子量	401.46
公式	C₁₇H₂₃N₃O.C₄H₄O₄
储存	Store at RT
CAS Number	59-33-6
PubChem ID	5284451
InChI Key	JXYWFNAQESKDNC-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mepyramine maleate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	40.15	100
	DMSO	40.15	100

制备储备液 for Mepyramine maleate

以下数据基于产品分子量 401.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.45 mL	24.91 mL
5 mM	0.5 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for Mepyramine maleate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mepyramine maleate

参考文献是支持产品生物活性的出版物。

Carlos et al (2004) Mepyramine, a histamine H₁ receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 279 34431 PMID: 15192105

Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Liu et al (1994) Does the [³H] mepyramine binding site represent the histamine H₁ receptor? Re-examination of the histamine H₂ receptor with qine J.Pharmacol.Exp.Ther. 268 959 PMID: 8114011

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关键词: Mepyramine maleate, Mepyramine maleate supplier, Selective, H1, inverse, agonists, Receptors, Histamine, histaminergic, Pyrilamine, maleate, 0660, Tocris Bioscience

5 篇 Mepyramine maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mepyramine maleate 的部分引用包括：

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Kurtz et al (2014) Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation 21 593 PMID: 24702851

Littmann et al (2018) A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells. Sci Rep 8 17179 PMID: 30464299

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Brandt et al (2003) Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 112 1666 PMID: 14660743

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