Methylmalonate

Cat. No. 4979 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Succinate dehydrogenase inhibitor

化学名： 2-Methylpropanedioic acid

纯度： ≥98%

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Methylmalonate

Methylmalonate is an intracellularly produced malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

技术数据 for Methylmalonate

分子量	118.09
公式	C₄H₆O₄
储存	Store at RT
纯度	≥98%
CAS Number	516-05-2
PubChem ID	487
InChI Key	ZIYVHBGGAOATLY-UHFFFAOYSA-N
Smiles	OC(C(C)C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Methylmalonate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	1.1eq. NaOH	11.81	100
	DMSO	11.81	100

制备储备液 for Methylmalonate

以下数据基于产品分子量 118.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	8.47 mL	42.34 mL	84.68 mL
5 mM	1.69 mL	8.47 mL	16.94 mL
10 mM	0.85 mL	4.23 mL	8.47 mL
50 mM	0.17 mL	0.85 mL	1.69 mL

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产品说明书 for Methylmalonate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Methylmalonate

参考文献是支持产品生物活性的出版物。

Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373 PMID: 15100720

McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279 PMID: 9692761

Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270 PMID: 22441874

If you know of a relevant reference for Methylmalonate, please let us know.

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关键词: Methylmalonate, Methylmalonate supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Other, Dehydrogenases, Oxidative, Phosphorylation, 4979, Tocris Bioscience

1 篇 Methylmalonate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Methylmalonate 的部分引用包括：

Belinskaia et al (2019) Psychotropic Drugs for the Management of Chronic Pain and Itch. Pharmaceuticals (Basel) 12 PMID: 31238561

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