MI 2 dihydrochloride

Name: MI 2 dihydrochloride
Brand: Tocris Bioscience
SKU: 4707

Cat. No. 4707 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4707 has been discontinued.

View all Other Lysine Methyltransferases products.

说明： Menin-MLL interaction inhibitor

化学名： 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for MI 2 dihydrochloride

Menin-MLL interaction inhibitor; binds menin (IC₅₀ = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

技术数据 for MI 2 dihydrochloride

分子量	448.48
公式	C₁₈H₂₅N₅S₂.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	6436801
InChI Key	OJCKRNPLOZHAOU-UGKRXNSESA-N
Smiles	CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MI 2 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MI 2 dihydrochloride

参考文献是支持产品生物活性的出版物。

Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128

Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID: 30923116

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篇 MI 2 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 MI 2 dihydrochloride 的引用文献。