Mianserin hydrochloride

Name: Mianserin hydrochloride
Brand: Tocris Bioscience
SKU: 0997

Cat. No. 0997 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0997 has been discontinued.

View all Non-selective 5-HT<sub>2</sub> products.

说明： 5-HT₂ antagonist. Has moderate affinity for 5-HT₆

化学名： 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Mianserin hydrochloride

Mianserin hydrochloride is a non-selective 5-HT₂ receptor antagonist (K_i values are 0.0080 and 0.0081 μM for human 5-HT_2A and 5-HT_2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT₆. Antidepressant.

技术数据 for Mianserin hydrochloride

分子量	300.83
公式	C₁₈H₂₀N₂.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	21535-47-7
PubChem ID	68551
InChI Key	YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Smiles	Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Mianserin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mianserin hydrochloride

参考文献是支持产品生物活性的出版物。

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301 PMID: 6282060

Merck Index 12 6260

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527

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关键词: Mianserin hydrochloride, Mianserin hydrochloride supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Non-selective, 5-HT6, 0997, Tocris Bioscience

2 篇 Mianserin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mianserin hydrochloride 的部分引用包括：

Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol 155 343 PMID: 18604238

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863 PMID: 20228179