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Submit ReviewMidazolam hydrochloride
说明： Benzodiazepine agonist
别名： Dormicum,Ro 21-3981/001
化学名： 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Midazolam hydrochloride
Midazolam hydrochloride is a sedative/hypnotic agent that acts at the GABAA receptor benzodiazepine modulatory site.
技术数据 for Midazolam hydrochloride
| 分子量 | 362.23 |
| 公式 | C18H13ClFN3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 59467-96-8 |
| PubChem ID | 43032 |
| InChI Key | PLYSCVSCYOQVRP-UHFFFAOYSA-N |
| Smiles | FC(C=CC=C4)=C4C3=NCC1=CN=C(C)N1C2=CC=C(Cl)C=C23.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Midazolam hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 9.06 | 25 |
制备储备液 for Midazolam hydrochloride
以下数据基于产品分子量 362.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.04 mL | 55.21 mL | 110.43 mL |
| 1.25 mM | 2.21 mL | 11.04 mL | 22.09 mL |
| 2.5 mM | 1.1 mL | 5.52 mL | 11.04 mL |
| 12.5 mM | 0.22 mL | 1.1 mL | 2.21 mL |
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产品说明书 for Midazolam hydrochloride
参考文献 for Midazolam hydrochloride
参考文献是支持产品生物活性的出版物。
Kanto (1985) Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy 5 138 PMID: 3161005
Olkkola and Ahonen (2008) Midazolam and other benzodiazepines. Handb.Exp.Pharmacol. 182 335 PMID: 18175099
If you know of a relevant reference for Midazolam hydrochloride, please let us know.
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关键词: Midazolam hydrochloride, Midazolam hydrochloride supplier, Benzodiazepine, agonists, GABAA, Receptors, Ro213981001, Dormicum, Ro, 21-3981/001, 2832, Tocris Bioscience
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Midazolam potentiates response of GABA-A receptors even in low concentration.
By
Anonymous on 08/17/2019
分析类型： In Vitro
种属： Rat
细胞系/组织： Cerebellum
Midazolam was used to test a response of GABA-A receptors in cerebellar granule cells; the compound has shown a clear potentiatory effect. Figure: evoked EPSCs under control (black) and with 10 microM of Midazolam in perfusion solution (white).
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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