Miglustat hydrochloride

Cat. No. 3117 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity

别名： N-Butyldeoxynojirimycin hydrochloride,NB-DNJ

化学名： (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Miglustat hydrochloride

Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

技术数据 for Miglustat hydrochloride

分子量	255.74
公式	C₁₀H₂₁NO₄.HCl
储存	Desiccate at -20°C
CAS Number	210110-90-0
PubChem ID	657399
InChI Key	QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Smiles	CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Miglustat hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	19.18	75
	DMSO	19.18	75

制备储备液 for Miglustat hydrochloride

以下数据基于产品分子量 255.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.75 mM	5.21 mL	26.07 mL	52.14 mL
3.75 mM	1.04 mL	5.21 mL	10.43 mL
7.5 mM	0.52 mL	2.61 mL	5.21 mL
37.5 mM	0.1 mL	0.52 mL	1.04 mL

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产品说明书 for Miglustat hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Miglustat hydrochloride

参考文献是支持产品生物活性的出版物。

Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362 PMID: 8132559

Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65 PMID: 12119611

Noel et al (2008) Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharmacol.Exp.Ther. 325 1016 PMID: 18309088

If you know of a relevant reference for Miglustat hydrochloride, please let us know.

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关键词: Miglustat hydrochloride, Miglustat hydrochloride supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, N-Butyldeoxynojirimycin, hydrochloride, NB-DNJ, Other, Transferases, Non-selective, Antivirals, 3117, Tocris Bioscience

1 篇 Miglustat hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Miglustat hydrochloride 的部分引用包括：

Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661 PMID: 21705667

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