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Submit ReviewMilameline hydrochloride
说明： Muscarinic receptor agonist
化学名： (E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Milameline hydrochloride
Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.
技术数据 for Milameline hydrochloride
| 分子量 | 190.67 |
| 公式 | C8H14N2O.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 139886-04-7 |
| PubChem ID | 9571001 |
| InChI Key | WEBMRZODPLSRKR-MLBSPLJJSA-N |
| Smiles | CN1CC(/C=N/OC)=CCC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Milameline hydrochloride
参考文献 for Milameline hydrochloride
参考文献是支持产品生物活性的出版物。
Sedman et al (1995) Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 56 877 PMID: 10188788
Wood et al (1999) Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br.J.Pharmacol. 126 1620 PMID: 10323594
Schwarz et al (1999) Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 291 812 PMID: 10525104
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关键词: Milameline hydrochloride, Milameline hydrochloride supplier, Muscarinic, receptors, agonists, Acetylcholine, ACh, Non-selective, Muscarinics, 2604, Tocris Bioscience
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