Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: Tocris Bioscience
SKU: 3286

Cat. No. 3286 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3286 has been discontinued.

View all 5-HT Transporters products.

说明： 5-HT and NA reuptake inhibitor (SNRI)

化学名： (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Milnacipran hydrochloride

Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC₅₀ values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α₁-adrenergic and 5-HT_2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

技术数据 for Milnacipran hydrochloride

分子量	282.81
公式	C₁₅H₂₂N₂O.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	101152-94-7
PubChem ID	73416954
InChI Key	GIGAIOSMEXBLQA-IBWNGBJLSA-N
Smiles	NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Milnacipran hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Milnacipran hydrochloride

参考文献是支持产品生物活性的出版物。

Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211 PMID: 3005901

Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α₁-adrenergic and serotonergic 5-HT_2A systems. J.Neural.Transm. 107 1345 PMID: 11145008

Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation. Anesth.Analg. 106 1309 PMID: 18349211

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关键词: Milnacipran hydrochloride, Milnacipran hydrochloride supplier, 5-HT, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, 3286, Tocris Bioscience

1 篇 Milnacipran hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Milnacipran hydrochloride 的部分引用包括：

Burnham and Dickenson (2013) The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther 344 696 PMID: 23297162