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Submit Review(-)-Bicuculline methiodide
说明： GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
化学名： [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
纯度： ≥99% (HPLC)
生物活性 for (-)-Bicuculline methiodide
(-)-Bicuculline methiodide is a methiodide form of classical GABAA receptor antagonist (+)-bicuculline. More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Methobromide Salt and Methochloride Salt also available.
技术数据 for (-)-Bicuculline methiodide
| 分子量 | 509.3 |
| 公式 | C21H20INO6 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 40709-69-1 |
| PubChem ID | 104871 |
| InChI Key | HKJKCPKPSSVUHY-GRTNUQQKSA-M |
| Smiles | [H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[I-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-Bicuculline methiodide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 10.19 | 20 | |
| DMSO | 25.46 | 50 |
制备储备液 for (-)-Bicuculline methiodide
以下数据基于产品分子量 509.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.93 mL | 19.63 mL | 39.27 mL |
| 2.5 mM | 0.79 mL | 3.93 mL | 7.85 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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产品说明书 for (-)-Bicuculline methiodide
参考文献 for (-)-Bicuculline methiodide
参考文献是支持产品生物活性的出版物。
Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283 PMID: 1247886
Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268 PMID: 10390643
Chan et al (2006) Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 55 1080 PMID: 16567532
Kurt et al (2006) Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex. Hear.Res. 212 224 PMID: 16442250
If you know of a relevant reference for (-)-Bicuculline methiodide, please let us know.
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关键词: (-)-Bicuculline methiodide, (-)-Bicuculline methiodide supplier, Water-soluble, GABAA, antagonists, Receptors, 2503, Tocris Bioscience
51 篇 (-)-Bicuculline methiodide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-Bicuculline methiodide 的部分引用包括：
Ye et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251
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Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Neurosci 10 e0124986 PMID: 25938462
Kempf et al (2014) The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol 12 e1001763 PMID: 24453941
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Namikawa et al (2018) Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice. Front Aging Neurosci 9 395 PMID: 29311894
Wang et al (2018) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron 98 90 PMID: 29576387
Hangen et al (2018) Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. Cell Rep 24 1001 PMID: 30044968
Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Pharmacol Res Perspect 31 3077 PMID: 21414928
Zhang and Lu (2017) Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis. J Biol Chem 292 15481 PMID: 28768764
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Francois et al (2017) A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron 93 822 PMID: 28162807
Medrihan et al (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron 95 564 PMID: 28735749
Fox and Hentges (2017) Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci 37 8667 PMID: 28821664
Cichon and Gan (2015) Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity. Nature 520 180 PMID: 25822789
Fehérvári et al (2015) In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse. PLoS One 10 e0133853 PMID: 26230520
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reliable product.
By
Anonymous on 04/04/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Sprague-Dawley rats primary neuronal
We increased synaptic activity using a standard pharmacological approach (20 μM bicuculline and 100 μM 4-AP.
Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By
Anonymous on 02/03/2020
分析类型： In Vivo
种属： Mouse
1mM Bicuculline
Bicuculline methiodide as a test tool of GABA-A receptor pharmacological properties.
By
Sergiy Sylantyev on 08/31/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Human embryo kidney cells
Bicuculline methiodide (Bic) was used to test GABA-A receptors pharmacological properties after expression in pre-transfected HEK cells. 100 microM of Bic fullu suppressed chloride current generated by application of 50 microM GABA at outside-out membrane patch. Figure: black trace - application of GABA, grey trace - application of GABA+Bic.
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