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Submit Review(-)-Cytisine
说明： Potent and selective neuronal nAChRagonist
化学名： (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
纯度： ≥99% (HPLC)
生物活性 for (-)-Cytisine
(-)-Cytisine is a potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.
技术数据 for (-)-Cytisine
| 分子量 | 190.24 |
| 公式 | C11H14N2O |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 485-35-8 |
| PubChem ID | 10235 |
| InChI Key | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
| Smiles | O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-Cytisine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for (-)-Cytisine
以下数据基于产品分子量 190.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.26 mL | 26.28 mL | 52.57 mL |
| 5 mM | 1.05 mL | 5.26 mL | 10.51 mL |
| 10 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.05 mL |
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产品说明书 for (-)-Cytisine
参考文献 for (-)-Cytisine
参考文献是支持产品生物活性的出版物。
Happe et al (1994) Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine. Neuroscience 62 929 PMID: 7870314
Papke et al (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol.Pharmacol. 45 142 PMID: 8302273
Reavill et al (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29 619 PMID: 2385332
If you know of a relevant reference for (-)-Cytisine, please let us know.
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关键词: (-)-Cytisine, (-)-Cytisine supplier, Potent, selective, neuronal, nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1390, Tocris Bioscience
2 篇 (-)-Cytisine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-Cytisine 的部分引用包括：
Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306
David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci 31 978 PMID: 20377613
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.