(-)-Nicotine ditartrate

Cat. No. 3546 12 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Prototypical nAChR agonist

化学名： (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt

纯度： ≥99% (HPLC)

引用文献 (12)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (K_i values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

技术数据 for (-)-Nicotine ditartrate

分子量	462.41
公式	C₁₀H₁₄N₂.2C₄H₆O₆
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	65-31-6
PubChem ID	11957628
InChI Key	RFEJUZJILGIRHQ-OMDKHLBYSA-N
Smiles	CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (-)-Nicotine ditartrate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	46.24	100
	DMSO	34.68	75

制备储备液 for (-)-Nicotine ditartrate

以下数据基于产品分子量 462.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.63 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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产品说明书 for (-)-Nicotine ditartrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (-)-Nicotine ditartrate

参考文献是支持产品生物活性的出版物。

Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626

Xiao et al (1998) Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 54 322 PMID: 9687574

Mayhan (1999) Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 133 48 PMID: 10385481

If you know of a relevant reference for (-)-Nicotine ditartrate, please let us know.

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关键词: (-)-Nicotine ditartrate, (-)-Nicotine ditartrate supplier, α4β2, agonists, a4b2, alpha4beta2, Nicotinic, Receptors, Acetylcholine, nAChR, (a4b2), (Non-selective), 3546, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Nicotine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

12 篇 (-)-Nicotine ditartrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (-)-Nicotine ditartrate 的部分引用包括：

Lena et al (2020) A molecular filter for the cnidarian stinging response. Elife 9 PMID: 32452384

David S et al (2020) NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Cell Rep 32 108025 PMID: 32783947

Tang et al (2015) Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Iran Biomed J 36 800 PMID: 25948478

Chalabi-Yani et al (2015) Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats. Elife 19 214 PMID: 26210948

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600

Dorst et al (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun 11 5113 PMID: 33037215

Gu et al (2019) α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep 26 866 PMID: 30673609

Leão et al (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15 1524 PMID: 23042082

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698

Marzena et al (2021) Chronic Lorcaserin Treatment Reverses the Nicotine Withdrawal-Induced Disruptions to Behavior and Maturation in Developing Neurons in the Hippocampus of Rats. Int J Mol Sci 22 PMID: 33467149

Jean-Marie et al (2022) β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue. Front Behav Neurosci 16 1004368 PMID: 36311864

Asami et al (2019) Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models. Neuron 101 444-458.e6 PMID: 30658860

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