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说明： Inhibitor of farnesyl diphosphate synthase (FPPS) and osteoclast-mediated bone resorption
别名： Alendronate sodium
化学名： P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt
生物活性 for MK 217
Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.
技术数据 for MK 217
| 分子量 | 271.08 |
| 公式 | C4H12NNaO7P2 |
| 储存 | Desiccate at -20°C |
| CAS Number | 129318-43-0 |
| PubChem ID | 62958 |
| InChI Key | CAKRAHQRJGUPIG-UHFFFAOYSA-M |
| Smiles | [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MK 217
参考文献 for MK 217
参考文献是支持产品生物活性的出版物。
Bergstrom et al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231 PMID: 10620343
Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945 PMID: 18974139
Fisher et al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96 133
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关键词: MK 217, MK 217 supplier, MK217, osteoclasts, mediated, bone, resorption, osteoporosis, inhibits, farnesyl, diphosphate, synthase, inhibitors, Alendronate, sodium, Other, Synthases/Synthetases, 4014, Tocris Bioscience
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