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MK 386

Cat. No. 5842 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective human type 1 5α-reductase inhibitor
化学名： (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MK 386

MK 386 is a potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.

技术数据 for MK 386

分子量 415.69
公式 C28H49NO
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 158493-17-5
PubChem ID 178013
InChI Key XUTZDXHKQDPUMA-UHFFFAOYSA-N
Smiles [H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 386

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.57 100

制备储备液 for MK 386

以下数据基于产品分子量 415.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.06 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for MK 386

参考文献是支持产品生物活性的出版物。

Schwartz et al (1997) MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J.Clin.Endocrinol.Metab. 82 1373 PMID: 9141518

Bakshi et al (1994) 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J.Med.Chem. 37 3871 PMID: 7966146

If you know of a relevant reference for MK 386, please let us know.

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关键词: MK 386, MK 386 supplier, MK386, Inhibitors, inhibits, 5alpha, reductase, 5a, 5α, 5alphaR, 5aR, 5αR, type, 1, testosterone, dihydrotestosterone, DHT, steroid, hormone, Other, Reductase, Androgen, Receptor, 5842, Tocris Bioscience

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