MK 886

Cat. No. 1311 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibitor of 5-lipoxygenase-activating protein (FLAP)

别名： L-663,536

化学名： 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid

纯度： ≥98% (HPLC)

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MK 886

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC₅₀ = 30 nM for inhibition of [¹²⁵I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC₅₀ = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC₅₀ = 0.5-1 μM). Orally active in vivo.

技术数据 for MK 886

分子量	472.08
公式	C₂₇H₃₄ClNO₂S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	118414-82-7
PubChem ID	3651377
InChI Key	QAOAOVKBIIKRNL-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3CN(C(CC(C)(C(O)=O)C)=C2SC(C)(C)C)C1=C2C=C(C(C)C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 886

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	2.36	5
	DMSO	47.21	100

制备储备液 for MK 886

以下数据基于产品分子量 472.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.59 mL	21.18 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for MK 886

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MK 886

参考文献是支持产品生物活性的出版物。

Dixon et al (1990) Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 282 PMID: 2300173

Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can.J.Physiol.Pharmacol. 67 456 PMID: 2548691

Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886. Biochem.J. 356 899 PMID: 11389700

Mancini et al (1992) 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol.Pharmacol. 41 267 PMID: 1538707

If you know of a relevant reference for MK 886, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Lipoxygenase Inhibitors

关键词: MK 886, MK 886 supplier, Inhibitor, 5-lipoxygenase-activating, protein, FLAP, PPARα, PPARalpha, antagonists, inhibitors, inhibits, Oxygenases, Oxidases, leukotrienes, eicosanoids, biosynthesis, Peroxisome, Proliferator-activated, PPARs, MK886, L663536, 5-LOX, L-663,536, Lipoxygenase, Receptors, Leukotriene, and, Related, 1311, Tocris Bioscience