MK6-83

Cat. No. 5547 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： TRPML channel activator

化学名： 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MK6-83

MK6-83 is a TRPML channel activator (EC₅₀ = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC₅₀ values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

技术数据 for MK6-83

分子量	336.47
公式	C₁₆H₂₀N₂O₂S₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1062271-24-2
PubChem ID	18191179
InChI Key	IRGYSXZCDAWOOC-UHFFFAOYSA-N
Smiles	CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK6-83

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.65	100
	ethanol	3.36	10

制备储备液 for MK6-83

以下数据基于产品分子量 336.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.72 mL
5 mM	0.59 mL	2.97 mL	5.94 mL
10 mM	0.3 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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产品说明书 for MK6-83

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MK6-83

参考文献是支持产品生物活性的出版物。

Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295

If you know of a relevant reference for MK6-83, please let us know.

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关键词: MK6-83, MK6-83 supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, 5547, Tocris Bioscience

2 篇 MK6-83 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MK6-83 的部分引用包括：

Steven J et al (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32 782-794 PMID: 29030399

Giancarlo et al (2023) RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun 14 2775 PMID: 37188688

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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