Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMKT 077
说明： Binds mot-2; selectively cytotoxic in cancer cells
化学名： 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
纯度： ≥98% (HPLC)
生物活性 for MKT 077
MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
技术数据 for MKT 077
| 分子量 | 432 |
| 公式 | C21H22ClN3OS2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 147366-41-4 |
| PubChem ID | 3037933 |
| InChI Key | VSKYOTRJSLYFHX-UXJRWBAGSA-M |
| Smiles | CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=C\C3=CC=CC=[N+]3CC)=O.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MKT 077
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 21.6 | 50 | |
| DMSO | 21.6 | 50 |
制备储备液 for MKT 077
以下数据基于产品分子量 432。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.63 mL | 23.15 mL | 46.3 mL |
| 2.5 mM | 0.93 mL | 4.63 mL | 9.26 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.93 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for MKT 077
参考文献 for MKT 077
参考文献是支持产品生物活性的出版物。
Wadhwa et al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818 PMID: 11156371
Wadhwa et al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434 PMID: 12154051
Tikoo et al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293 PMID: 10526670
Patury et al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337 PMID: 19860737
If you know of a relevant reference for MKT 077, please let us know.
按标靶查看相关产品
关键词: MKT 077, MKT 077 supplier, MKT077, heat, shock, proteins, 70, Hsp70, Hsps, inhibitors, inhibits, telomerase, F-actin, cross-linkers, 4621, Tocris Bioscience
1 篇 MKT 077 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MKT 077 的部分引用包括：
Chiaw et al (2019) Hsp70 and DNAJA2 limit CFTR levels through degradation. PLoS One 14 e0220984 PMID: 31408507
您是否知道使用了 Tocris MKT 077 的优秀论文？ 请告知我们.
MKT 077 的评论
目前没有该产品的评论。 Be the first to review MKT 077 and earn rewards!
Have you used MKT 077?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets