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ML 162

Cat. No. 7821 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits glutathione peroxidase (GPX4); induces ferroptosis
化学名： 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 162

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

技术数据 for ML 162

分子量 477.41
公式 C23H22Cl2N2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1035072-16-2
PubChem ID 3689413
InChI Key UNVKYJSNMVDZJE-UHFFFAOYSA-N
Smiles O=C(NCCC=1C=CC=CC1)C(C=2SC=CC2)N(C(=O)CCl)C3=CC=C(OC)C(Cl)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 162

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.74 100
ethanol 9.55 20

制备储备液 for ML 162

以下数据基于产品分子量 477.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for ML 162

参考文献是支持产品生物活性的出版物。

Luo et al (2022) Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angew.Chem.Int.Ed.Engl. 39 e202206277 PMID: 35924720

Karaj et al (2022) Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J.Med.Chem. 65 11788 PMID: 35984756

Weïwer et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 22 1822 PMID: 22297109

If you know of a relevant reference for ML 162, please let us know.

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关键词: ML 162, ML 162 supplier, ML162, ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, covalent, inhibitors, inhibits, Ferroptosis, Other, Reductase, 7821, Tocris Bioscience

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