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ML 179

Cat. No. 4957 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective liver receptor homolog 1 (LRH1) inverse agonist
化学名： 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 179

ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

技术数据 for ML 179

分子量 422.44
公式 C21H25F3N4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1883548-87-5
PubChem ID 45100448
InChI Key MFABFKUNLDYKGH-UHFFFAOYSA-N
Smiles O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 179

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 21.12 50

制备储备液 for ML 179

以下数据基于产品分子量 422.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.73 mL 23.67 mL 47.34 mL
2.5 mM 0.95 mL 4.73 mL 9.47 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
25 mM 0.09 mL 0.47 mL 0.95 mL

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参考文献 for ML 179

参考文献是支持产品生物活性的出版物。

Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964

If you know of a relevant reference for ML 179, please let us know.

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关键词: ML 179, ML 179 supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, 4957, Tocris Bioscience

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ML 179 的评论

平均评分: 4 (Based on 1 Review.)

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Selective liver receptor homolog 1 (LRH1) inverse agonist.
By Anonymous on 11/16/2018
分析类型： In Vitro
种属： Human
细胞系/组织： BT-474

breast cancer cells line

Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).